Cytokine-induced Neurogenesis for Alzheimer's Disease and Frontotemporal Dementia

Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two major causes of dementia. These diseases both progressive neurodegenerative whereas no curative treatment has not yet been established. Regenerative approaches have extensively researched for AD FTD, but they still in early phase pre-clinical trials. We show here, the first time, that cytokines such as hepatocyte growth factor (HGF), granulocyte colony stimulating (GCSF), insulin-like factors (IGFs), progranulin (PGRN) can induce neurogenesis GABAergic glutamatergic neurons cerebral cortex hippocampi FTD patients. also showed evidence, atrophied were significantly regenerated by cytokine-induced patients, which was confirmed MRI study neurophysiological evaluations. therefore explored potentiality cytokine cocktail is a novel promising strategy to cure FTD.